Online Agenda
8:45 am
Login & Virtual Coffee Chat
9:00 am
Chair’s Welcome
9:10 am Introducing Next Generation Capture Resins into Continuous Processing Applications
Synopsis
- Investigated implementation of different Protein A resins into platform capture step in both batch and continuous processing
- For continuous processing, next generation resins can offer improved productivity through decreased residence times. However, molecule-specific properties and platformed buffer selections often demand that the process be understood holistically, not just maximized for loading
- Impurity clearance remains comparable to batch operations. Yield and cost-of-goods (resin, buffer, operator hours) become key drivers for differentiation
9:30 am Strategy for Implementation of PI in a Diverse Manufacturing Environment
Synopsis
- Using a combination of lab scale data and process modelling to develop a business case for evaluating PI to fit in Janssen’s facilities
9:50 am Design of Jetted Protein A Resins for Continuous Chromatography
Synopsis
- Scalable, continuous ‘Jetting’ technology to produce beads with a narrow particle-size distribution
- Considerations of dynamic binding capacity (DBC), purification performance, cleaning in place and fouling of chromatography resins
- Proven data to demonstrate improved process economics in commercial manufacturing
10:10 am Live Q&A – Ask Our Speakers Your Burning Questions
10:20 am
Virtual Speed Networking
11:00 am Think Tank Fireside Chat: How to Turn Continuous Bioprocessing into Reality?
Synopsis
- What needs to happen? From interest to real commitment
- Downstream processing in biologics – challenges and opportunities
- The choice of equipment and platform – sticking with what you know vs choosing what is right for you?
- Adopting resin to platform or platform to resin?
- Quality and qualification